Cheri R.

• Designed and synthesized hundreds of molecules that significantly contributed to an NRAS-selective inhibitor program. • Validated and expanded hits from DNA-encoded library screening, affinity selection mass spectrometry screening, fragment-based screening, and virtual screening across multiple precision oncology and genetic disease projects. • Designed bespoke compounds and compound libraries to optimize potency, physicochemical and ADME properties, utilizing computation tools to aid in decision-making. • Collaborated cross-functionally with computational, biophysical, biochemical, and biological teams to successfully achieve project goals within defined timelines. • Rapidly expanded SAR on chemical series through implementation of nanoSAR and high throughput purification by working closely with the chemical technologies, computational, and biochemical teams. • Identified, designed, and synthesized chemical probes to enable screening efforts and target validation. • Managed contract research organization (CRO) teams to efficiently drive programs forward and meet critical deadlines. • Served as Chemical Hygiene Officer, ensuring compliance with safety regulations and protocols.

• Designed and synthesized heterobifunctional molecules to support Radial Therapeutics’ platform development; also managed external synthesis in support of this effort. • Established in-house antisense oligonucleotide synthesis capabilities to support chemistry programs. • Developed a protocol to synthesize, purify, and QC >50 compounds in parallel on a nanogram scale.

• Contributed to the design and synthesis of compounds for program indications of obesity (leading to pre-clinical candidate KTX-0200), colorectal cancer, Parkinson’s disease, chronic kidney disease, and multiple sclerosis. • Executed multi-step syntheses of structurally diverse compounds on a milligram to multi-gram scale. • Designed and synthesized small molecule therapeutics for site-specific delivery of bioactive compounds to support Kintai’s Precision Enteric Medicine™ platform. • Managed an external team of chemists at a contract research organization (CRO) to support a synthetically challenging program. • Established and maintained a safe and efficient organic chemistry lab by sourcing equipment, managing service contracts, and overseeing the purchase, inventory, and organization consumables and reagents. • Supervised and mentored a chemistry co-op student throughout her 6-month internship.

• Contributed to medicinal chemistry efforts which led to an orally efficacious development candidate targeting IDO and enhanced potency and pharmacokinetic properties of a lead series targeting IL-17A. • Effectively designed and synthesized compounds to drive SAR exploration, leading to improvements in affinity and pharmacokinetic properties across multiple series in various therapeutic areas, including cardiovascular, inflammation, and oncology. • Designed and executed multi-step syntheses of building blocks and final macrocyclic compounds to support hit validation for several internal and partnered projects. • Efficiently synthesized hundreds of peptides using automated solid-phase peptide synthesis techniques. • Provided training and mentorship to interns and new chemistry team members.

• Developed a novel procedure for the synthesis of polyketide-derived macrocycles utilizing reductive amination as a key step.

• Worked in the Laboratory for Neglected Disease Drug Discovery under the supervision of Dr. Michael Pollastri. • Designed and synthesized a diverse library of hydroxamic acids as potential Trp-DAC inhibitors utilizing parallel solid-phase synthetic techniques.

• Organized and prepared biological specimen for testing. • Performed basic medical tests on specimens and assisted with advanced tests. • Trained and supervised an intern in the department. • Assisted with phlebotomy.