Charlie C.

Charlie C.

Consultant

About

Passionate and curious medicinal chemist with fifteen years of experience in small, medium and large biotech/pharma companies. • Key contributor to two Tubulysin based clinical antibody drug conjugate programs for cancer. • Experience as program chemistry lead in cross-functional team. • Excellent lab skills and ability to make good use of modern equipment in a medicinal chemistry lab. • Comfortable with designing and synthesizing biologically active small molecules ranging from heterocycles to natural products and cyclic dinucleotides. • Expertise in structure-based drug design to address program challenges (potency, selectivity, metabolic stability, hERG, CYP, PK, in-vitro and in-vivo pharmacology, intellectual property (IP)). • Extensive use of x-ray structure, Livedesign, Mastro and Lead discovery for CADD and visualization. • Experience with effective utilization of CRO to support chemistry needs.

Country

United States

City

Sunnyvale

Industry

Biotechnology

Skill

Medicinal Chemistry, Antibody Drug Conjugates, Small Molecules Drug Discovery, Pharmaceutical Industry, Biotechnology, Pharmacology, High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), Nuclear Magnetic Resonance (NMR), Heterocycle synthesis, SAR development, Lead Optimisation, Payload Synthesis, Linker Synthesis, Pharmacokinetics, immunomodulator, Patent Preparation, X-Ray, Peptide synthesizer, Maestro

Experience

Consultant

2023-11 - Present · 2 yrs 11 mos

Consultant for Whitehawk Therapeutics, from 2025 - Current Providing subject matter expertise in the area of Antibody-Drug Conjugate development, manufacture and testing. Helped with two successful IND applications that received FDA clearance

Nine Square Therapeutics

Principal Scientist

Nine Square Therapeutics

LinkedIn
2022-2 - 2023-10 · 1 yr 9 mos

Project chemistry lead for small molecule CNS drug, activities: hit generation through virtual screening and HTS, hit expansion, lead generation and optimization, formulation and execution of medicinal chemistry strategy, management of CRO and assembling of information for IP filings.

SRI

Senior Research Scientist - Medicinal Chemistry Automation

SRI

LinkedIn
2021-7 - 2021-10 · 4 mos

Menlo Park, California, United States

• Medicinal Chemistry Designer for Small Molecule Programs Using SynFini Automated Chemistry Platform (Based on AI, Parallel and Flow Chemistry)

CS-Bay Therapeutics

Director of Medicinal Chemistry

CS-Bay Therapeutics

2020-11 - 2021-5 · 7 mos

Newark, California, United States

• Antibody-Drug-Conjugate R&D for Cancer

Bristol Myers Squibb

Senior Research Investigator I

Bristol Myers Squibb

LinkedIn
2011-8 - 2020-8 · 9 yrs 1 mo

Redwood City, CA

• Made significant impact on small molecule TLR7 program. • Acted as chemistry lead for initiation of TLR7 Antibody Drug Conjugate (ADC) program.

Medarex (Acquired by BMS in May 2009)

Scientist II

Medarex (Acquired by BMS in May 2009)

2008-8 - 2011-7 · 3 yrs

Sunnyvale, CA

• Key contributor to two Tubulysin-based clinical ADC programs.

Medarex

Scientist I

Medarex

LinkedIn
2006-8 - 2008-7 · 2 yrs

Sunnyvale, CA

• Modified literature routes to facilitate Tubulysin analog synthesis. • Provided CBI analogs with modified hydrazones for extended serum stability.

Galileo Pharmaceuticals, Inc.

Scientist

Galileo Pharmaceuticals, Inc.

LinkedIn
2004-11 - 2006-4 · 1 yr 6 mos

Santa Clara, CA

• Designed and executed synthesis of analogs for inhibitors of 15-lypoxygenase

Education

UC San Diego

UC San Diego

LinkedIn

Organic Chemistry

1998 - 2004 · 6 yrs
Saint Louis University

Saint Louis University

LinkedIn

Organic Chemistry

1996 - 1998 · 2 yrs
Dalian University of Technology

Dalian University of Technology

LinkedIn

Chemical Engineering

1990 - 1995 · 5 yrs

Charlie C.'s Contact Information

Email

******@***.com

Phone

(**) *** ****

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