Changhui Liu

Radiochemist @ Moravek, Inc

About

Organic/synthetic/radio chemist for more than 20 years with extensive GMP/GLP radiochemical synthesis, drug discovery experience in both therapeutic and diagnostic areas (Oncology and CNS). Dedicated to high quality research and high productivity in the lab illustrated by co-authoring 31 publications/presentations/patents. Extensive experience in synthesis of Hits follow-up (HF) libraries. Expertise in drug design to improve potency and skilled in the multi-step synthesis of complex small molecules. Expertise in modern forms of liquid chromatography and method development for analytical and preparatory HPLC functionality. Also proficient in all areas of peptide research including modern synthetic techniques, structural analysis, and purification. Broad industry experience from start-up to big company. Excellent communication, data analysis, and problem-solving skills. Quick learner of new technical skills and new instrument processes to move a project forward. Work Experience Skills: Radio/Organic/Medicinal chemistry GMP/GLP radio API synthesis Drug design, SARs development and interpretation PET imaging agent design and synthesis Peptide synthesis and structural analysis Parallel synthesis/Hits follow-up library synthesis Solid phase synthesis and purification methods Design and synthesis of Antibody Drug Conjugates (ADC) Analytical and Process chemistry HPLC method development Hit-to-lead validation and lead optimization

Country

United States

City

Walnut

Industry

Pharmaceuticals

Skill

Nuclear Chemistry, Radioactivity, Radiochemistry, Organic Chemistry, Medicinal Chemistry, Combinatorial Chemistry, NMR, HPLC, Chemistry, Organic Synthesis, Analytical Chemistry, Chromatography, Mass Spectrometry, LC-MS, Purification, Spectroscopy, Fluorescence, Drug Design, Drug Discovery, UV/Vis

Experience

Radiochemist

Moravek, Inc

2013-8 - Present · 13 yrs 2 mos

Los Angeles Metropolitan Area

Senior Scientist

Concortis Biosystem, Inc.

2013-1 - 2013-7 · 7 mos

Design and synthesis of Antibody Drug Conjugates (ADC). Contributed in synthesis of ADC toxin precursors with disulfide linkers and pentafluorophenol (PFP) ester linkers

Scientist II

Siemens Molecular Imaging, Inc

2009-3 - 2013-1 · 3 yrs 11 mos

Alzheimer Disease projects (Tau tracer) Design and synthesis of new PET tracers that selectively bind to Tau against β-Amyloid. Prostate cancer projects (PSMA tracer) Design and synthesis of new dimeric PET tracers that bind to PSMA at picomolar range. My lead compound was selected as a clinical candidate. Caspase 3 projects (Apoptosis tracer) Design and synthesis of PEGylated PET tracers that detect apoptotic cells with higher level of Caspase 3.

Research Scientist

ChemBridge Research Laboratories, Inc

2004-6 - 2009-3 · 4 yrs 10 mos

Parasynthesis of Hits-Follow up (HF) libraries including protocol developments, protocol validations, just in time monomers synthesis, library productions and purifications. Medicinal chemistry support for internal research HIV projects including synthesis of key intermediates and production of small HF libraries. Synthesis of important pharmaceutical intermediates and building blocks

Graduate research assistant

Virginia Tech

1999-8 - 2004-5 · 4 yrs 10 mos

Design and synthesis of steroid-linked paclitaxel analogs for selective delivery of anticancer drug to estrogen receptor (ER) positive breast cancer cells. Preparation of fluorescent baccatin III analogs, fluorescent paclitaxel side chain, and other modified paclitaxel analogs for tubulin binding analysis. Preparation of thio-containing paclitaxel analogs as gold binding agents to investigate biological binding conformation and drug targeting through gold nanoparticles. Design and synthesis of conformationally restricted macrocyclic and cyclopropanated paclitaxel analogs for elucidation of the binding conformation.