Brian Law

Senior Scientist @ Hinge Bio

About

I am a biologist with extensive experience in preclinical drug discovery and translational biology with a proven track record of supporting successful IND filings and FDA approvals. I have served as lead biologist and/or supporter of multiple discovery and late stage programs e.g., high throughput screening, in vitro and ex vivo cellular assay development, MOA, and biomarker discovery. I sponsored and managed CRO studies supporting SAR of multiple programs e.g., study design and execution of preclinical rodent studies (PK, PKPD, efficacy), biochemical assays, and NGS. Additionally, I have experience in building laboratories and biology teams, training and supporting scientists, lab and facilities management, capital/fixed assets procurement and budgeting, and domestic and international compliance (EHS, Cal OSHA, GLP, and IACUC). Beyond the scope of work, I have passion in writing music, exploring outdoors, cooking, and traveling.

Country

United States

City

San Francisco Bay Area

Industry

Biotechnology

Skill

Autologous B-cell Depletion, Antibody-dependent cellular cytotoxicity (ADCC), Antibody-dependent cellular phagocytosis (ADCP), Antibody Dependent Cellular Cytotoxicity (ADCC), Antibody Dependent Cellular Phagocytosis (ADCP), Cytotoxicity, Antidrug Antibody, LAL Testing, Cell Based Assays, Cancer Biology, PK/PD, Experimental Design, Biomarker Discovery, High Throughput Screening, Study Design, NanoString, WESS/JESS Automated Western, Cell Biology, Molecular Biology, Drug Development

Experience

Senior Scientist

Hinge Bio

2026-1 - Present · 9 mos

Scientist

Hinge Bio

2023-9 - 2025-12 · 2 yrs 4 mos

Support development of biologics for autoimmune diseases. -Developed flow cytometry based cell binding assays (indirect and competition) to screen protein library using cell lines and primary cells for lead selection. -Functionally characterize leads against clinical translationally relevant agents using flow cytometry (ADCC, ADCP, and Autologous B-cell Depletion).

Scientist

Biomea Fusion

2021-12 - 2023-2 · 1 yr 3 mos

Biology project lead for multiple programs. -Contributed to at least 3 Go/No-Go drug development programs. -Preclinical pharmacology lead for pipeline programs. -High throughput compound library screening supporting SAR and lead optimized molecule selection. -Biomarker strategy, MOA, assay development and execution. -Execution of data and report submissions supporting successful IND filings. -Well versed with EHS - OSHA/CAL OSHA, IACUC, and GxP practice and guidelines. -Adept with lab builds and lab moves.

Associate Scientist

Biomea Fusion

2021-1 - 2021-12 · 1 yr

Associate Scientist

AstraZeneca

2020-6 - 2021-1 · 8 mos

South San Francisco, California, United States

Research Associate II

Acerta Pharma B.V. (A member of the AstraZeneca Group)

2015-10 - 2020-6 · 4 yrs 9 mos

San Carlos, CA

-High dimensional spectral flow cytometry (20+ color B&T-cell panels) -Assay development and panel design -Mammalian and primary cell culture (suspension and adherent) -In vitro/ex vivo cell based assays -PBMC/BMMC/Lymph Node MC isolation and cryopreservation -NanoString gene expression assays -Westerns -ELISA -Laboratory management -Safety (EHS)