Brenda B Smith

Head of Toxicology and Biocompatibility @ Glaukos Corporation

About

Diplomate, ABT (2009) Specialties: Developing preclinical toxicology programs for biotherapeutics, small molecules and medical devices. Early discovery to late-stage development & life-cycle management. Experience in various therapeutic areas including ophthalmology, oncology, asthma, neurology, pain, and dermatology.

Country

United States

City

Salt Lake City Metropolitan Area

Industry

Biotechnology

Skill

Toxicology, GLP, IND, Medical Devices, Pharmaceuticals, CRO, Regulatory Submissions, Pharmaceutical Industry, Lifesciences, In Vivo, Clinical Development, FDA, In Vitro, Oncology, Pharmacokinetics, R&D, Biotechnology, Drug Development

Experience

Head of Toxicology and Biocompatibility

Glaukos Corporation

2025-11 - Present · 11 mos

Aliso Viejo, California, United States

Senior Director, Head of Toxicology

Eikon Therapeutics

2023-10 - 2025-11 · 2 yrs 2 mos

San Francisco Bay Area

Senior Director, Nonclinical

Vir Biotechnology, Inc.

2020-8 - 2023-8 · 3 yrs 1 mo

Head of Toxicology and DMPK

Director of Toxicology

AbbVie

2020-5 - 2020-8 · 4 mos

Irvine, California, United States

Director

Allergan

2018-3 - 2020-5 · 2 yrs 3 mos

Irvine, California

Associate Director

Allergan

2013-7 - 2018-3 · 4 yrs 9 mos

Irvine, California

Co-manage toxicology department of 13 PhD level toxicologists. Provide toxicology support to Nonclinical Development Team in the therapeutic areas of ophthalmology and neurology and serve as representative to multi-functional Core Team for development projects.

Associate Director, Pharmaceutical Toxicology

Alcon

2010-6 - 2013-7 · 3 yrs 2 mos

Served as project team representative for as many as 13 ophthalmology pharmaceutical products in development; limited involvement in biocompatibility testing for plastics and medical devices and preclinical development for surgical devices.

Lead Research Investigator I

Sanofi

2009-1 - 2009-12 · 1 yr

Principal Research Investigator

Sanofi

2005-8 - 2008-12 · 3 yrs 5 mos

Senior Research Toxicologist

Merck & Co, Inc

2004-6 - 2005-8 · 1 yr 3 mos

Research Scientist II

Amgen Inc

2002-6 - 2004-6 · 2 yrs 1 mo

Graduate Research Associate

The University of Kansas

1998-8 - 2002-5 · 3 yrs 10 mos

Graduate research included behavioral and histomorphological analysis of rats with 6-Hydroxydopamine-induced Parkinsonism and behavioral sensitization as a result of chronic treatment with drugs of abuse.