Brandon D'Arcy
Principal Scientist, Structural Biology @ Kimia Therapeutics
About
Experience executing and managing multiple projects in the following areas: •Ten years of experience in biochemistry and molecular biology •Five years of experience in structural biology crystallizing protein-inhibitor/ligand complexes •Advanced training in X-ray crystallography and Small Angle X-ray Scattering •Expertise in genome engineering using Cas9-based methods and lentiviral transduction for generating stable cell lines harboring genetic disruptions and modified genes. •Author of eight publications in peer-reviewed journals including five first-author papers and one patent.
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United States
Pharmaceuticals
X-ray crystallography, Protein Crystallization, Protein Purification, Data Processing, Molecular Cloning, Protein Expression, Assay Development, Chromatography, High-Performance Liquid Chromatography (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), Recombinant Protein Expression, Insect Cell Culture, Coot (Software), Polymerase Chain Reaction (PCR), SDS-PAGE, Western Blotting, Flow Cytometry, Reverse Transcription Polymerase Chain Reaction (RT-PCR), Immunohistochemistry, Confocal Microscopy
Experience
Principal Scientist, Structural Biology
Kimia Therapeutics
Berkeley, California, United States
Senior Scientist
Loxo@Lilly
South San Francisco, California, United States
Postdoctoral Researcher
University of South Alabama
Mobile, Alabama, United States
• Demonstrated LB-100, a small molecule protein phosphatase inhibitor, targets both PPP2AC and PPP5C using X-ray crystallography, dose response assays, and cell-based studies • Contributed to the development of pro-drugs for the specific inhibition of serine/threonine protein phosphatase using X-ray crystallography and structure-aided drug design • Characterized the structural and functional effects of clinically relevant missense mutations in the PMS2 gene using biochemical assays, Small Angle X-ray Scattering, and X-ray crystallography
Education
University of South Alabama
Department of Biochemistry and Molecular Biology
Developed methods to enable cholesterol ring degradation in human cells, which are now licensed to and being further developed by Repair Biotechnologies
Brandon D'Arcy's Contact Information
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