Boopathy sivaraman

Associate Scientist @ Biocon

Country

India

City

Bengaluru

Industry

Research

Skill

DNA Extraction, Oncology, Immunology, Data Management, Real-Time Polymerase Chain Reaction (qPCR), Flow Cytometry, Laboratory Skills, Medical Research, Data Analysis,  Review literature and present information on relevant therapeutic targets for, Preparation of SOP and new model proposal for inflammation and metabolic platfor,  Proposed protocol for standardized in-vitro and in-vivo model for Non Alcoholi,  Worked on Ideation and new product concept development for diabetes, immunity, Handling of laboratory animals like mice,rat,guinea pig,hamster and rabbit., Routes of administration in animals: p.o, i.p, i.v, i.t, i.n and subcutaneous., Blood collection: retro orbital, tail milking, heart puncturing and saphenous ve, In vitro: Handling of various human cancer and mouse cancer derived cell lines, DNA related techniques: Genomic DNA and plasmid DNA isolation, Restriction dige, Protein Techniques: Isolation of histone proteins, Native and SDS-PAGE and West, Biochemical Assays: Total leucocyte count,differentaial count, Triglyceride,ALP

Experience

Associate Scientist

Biocon

2013-6 - Present · 13 yrs 4 mos

Bengaluru Area, India

Protocol (SOP) preparation and new proposal writing for various inflammatory studies. Preparation of protocols for IAEC approvals. Assay Development for Pro & anti Inflammatory marker.., Focusing on establishment and validation of new animal models on various therapeutic areas like Sepsis model in mice and Imiqumod induced psoriasis in mice model. Involved in efficacy studies for pre-clinical development of anti-inflammatory drugs covering • LPS induced pulmonary inflammation, • Chronic Obstructive Pulmonary disease (COPD) • Bleomycin induced pulmonary fibrosis, • Thioglycollate induced peritonitis, • Apomorphine induced stomatitis • Carrageenan induced paw edema • DSS induced colitis • CCl4 induced liver cirrhosis

Senior Research Associate

Abbott

2012-6 - 2013-6 · 1 yr 1 mo

Bengaluru Area, India

Proposed protocol for standardized in-vitro and in-vivo model for Non Alcoholic Fatty Liver Disease (NAFLD). Worked on Ideation and new product concept development for diabetes, immunity and inflammation platforms Involving in scientifically execution and facilitation of in vivo, ex vivo and in vitro studies related to Diabetes (PPGC), pulmonary inflammation (COPD/fibrosis). Reviewed the literature and presented information on relevant therapeutic targets for auto-immune/inflammatory disorders, analyzed the data, performed statistical analyses and prepared presentations for internal group and project team meetings

Research fellow

Indian Institute of Science (IISc)

2009-3 - 2012-6 · 3 yrs 4 mos

Bengaluru Area, India

Involved in Histone Post translation modification (propionylation, Acetylation and phosphorylation) in cancerous cell lines by treating different classes of chemotherapeutic drugs such as DNA alkylating (Temozolomide) and histone de-acetylase inhibitors.