Boaz Hirshberg

Senior Vice President, Clinical Development Unit Head, Internal Medicine. Leading strategic program direction as well as early and late stage clinical development for a broad range of therapeutic areas including Obesity, ophthalmology, Immunology, inflammation, infectious, cardiovascular, metabolic and rare diseases.

Senior Vice President, Clinical Sciences General Medicine, leading strategic program direction and late-stage clinical development for a broad range of therapeutic areas including ophthalmology, cardiovascular and metabolic, pain and neurology, and infectious and rare diseases.

Title: Head of Clinical Development | Member, Executive Leadership Team Summary: Directed all aspects of clinical development strategy and execution across the company’s portfolio of novel therapeutics. Served on the senior executive team, contributing to corporate clinical research strategy, portfolio prioritization, and external partnerships. Key Achievements: • Established and led the global clinical development function, integrating medical, regulatory, and operational components. • Oversaw clinical program design, regulatory submissions, and cross-functional governance. • Evaluated and integrated external licensing and partnership opportunities across academia Impact: Built a high-performing clinical organization from the ground up and guided several programs through critical milestones.

Vice President, Clinical Therapeutic Area Head, Cardiovascular Renal and Metabolism (CVRM) at MedImmune, the biotech arm of the AstraZeneca. Accountable for all early clinical development plans and clinical trials within CVRM; chairing the CVRM Clinical Functional Review Committee (FRC) and Protocol Review Committee (PRC), respectively; serving as core member of the MedImmune Safety Review Board (MSRB). Visionary leader, committed to bringing scientific innovation to early and late clinical trials, currently focused patient centricity and on the use of digital technologies and AI to expand data sets and improve the patient experience. Key Achievements: * Defined and executed integrated early development strategy from candidate selection through Phase 2 * Directed multiple global programs in diabetes, dyslipidemia, and renal/metabolic diseases * Partnered with research, regulatory, and commercial functions to ensure seamless advancement from early to late-stage development. * Drove portfolio governance and cross-functional decision-making across R&D. Impact: Advanced MedImmune’s CVRM portfolio through early clinical success and efficient program transitions to late-stage development, positioning the organization for long-term therapeutic leadership in metabolic disease.

Served as Global Clinical Lead for the saxagliptin (Onglyza) franchise, guiding its life-cycle management and post-approval studies. In partnership with BMS, led the Qtern (dapagliflozin/saxagliptin) development and NDA submission. Qtern was approved by the the EU in July 2016 and FDA in February 2017 as a once-daily treatment for type 2 diabetes, Qtern is a combination medication containing dapagliflozin, an SGLT2 inhibitor, and saxagliptin, a DPP-4 inhibitor. Its development followed the approval of the individual components

Senior Director, Clinical Research Led global programs including the $250M, 16,500-patient SAVOR cardiovascular outcomes trial, and contributed to multiple successful NDA and sNDA submissions.

Clinical research in diabetes, cardiovascular outcome study, Study lead for the SAVOR outcome study as well as several additional phase 3 studies. Member of the team developing Komboglyze: medication that combines two different drugs—saxagliptin and metformin In partnership with Abbott, served as clinician for the development of a combination including Crestor (rosuvastatin), a statin for lowering LDL cholesterol, and Abbott's fenofibrate or next-generation fenofibrate (ABT-335) to manage triglycerides and HDL ("good") cholesterol.

Early clinical lead, diabetes

Endocrine Fellowship, NIDDK, NIH

Hadassah Medical Center, Ein Karem, Israel

Medical School