Bishal Tandukar, PhD
Postdoctoral Research Scientist @ University of California, San Francisco
About
Senior postdoctoral scientist with 12+ years of experience in skin biology, stem cell biology, and cancer genomics, specializing in single-cell and spatial transcriptomics. I bring deep expertise in next-generation sequencing (NGS), patient-derived samples, and integrative genomic analysis to support translational and data-driven discovery. My work focuses on decoding genomic and transcriptomic alterations in skin cells relevant to cancer and tissue homeostasis, including melanocytes, keratinocytes, fibroblasts, and stem cell populations. Using advanced experimental and computational approaches, I analyze DNA damage patterns and gene expression programs at single-cell resolution to uncover mechanisms of disease progression, stem cell dysfunction, and therapeutic response. I am experienced in developing and optimizing both wet-lab assays and bioinformatic pipelines, bridging experimental biology with scalable data analysis. I have a strong publication record in high-impact journals, including Nature Cell Biology, Nature Communications, and Science Advances, and have contributed to multi-institutional research efforts with clear translational goals. I am comfortable working across disciplines and collaborating with diverse teams to move complex datasets toward actionable biological insights. Beyond research execution, I value communication, mentorship, and teamwork. I have trained junior scientists and contributed to scientific communication initiatives, helping translate complex results for broader audiences. I am motivated to apply my expertise in a setting, where rigorous science, collaboration, and innovation converge to advance precision medicine and develop impactful therapeutic strategies.
United States
South San Francisco
Higher Education
Next-Generation Sequencing (NGS), Spatial transcriptomics (10X Visium and Xenium), Next Generation Sequencing, G&T sequencing, DNA sequencing and RNA sequencing, R (Programming Language), RNAseq Analysis, Primary cell (including stem cell) isolation and culture from both human and mouse, Immunofluorescence, Fluorescence activated cell sorting (FACS), Stem cell culture in both adherent and non-adherant (spheroid) conditions for maintenance , treatment and differentiation, Subcutaneous, intraperitoneal, intravitreous, intradermal, intracranial and retro-orbital injection and innoculation of mice, Sequence Alignment, Statistics, Flow Cytometry, In vivo BrdU labeling, Programming, Mass Spectrometry, S200 size exclusion, Immunohistochemistry, Dissection for mouse embryo and tissue extraction
Experience
Postdoctoral Research Scientist
University of California, San Francisco
San Francisco, California, United States
• Principal Investigator: Dr. Hunter Shain • Department of Dermatology, UCSF • Genomic study of human skin at the resolution of single cell to look at the mutational landscape and understand the origin as well as the drivers of skin cancers like melanoma
Graduate Research Assistant
University of Maryland, Baltimore (UMB)
Baltimore, Maryland, United States
• Principal investigator: Thomas J. Hornyak MD PhD • Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore • Thesis Project: Melanocyte stem cells subpopulations show distinct pigmentation and regenerative potential • Characterized Dct-H2BGFP and B6-Dct-H2BGFP mouse models permitting accurate identification of melanocytes and their stem cells by constitutive GFP expression • Compared the transcriptomes of melanocyte stem cells from the bulge and secondary hair germ (SHG) region of hair follicle (HF) by genome-wide expression profiling (RNA-seq) • Identified heterogeneous melanocyte stem cells subpopulations with distinct pigmentation and regenerative potential for the first time • Showed that a melanocyte stem cell subpopulation exhibited the ability to myelinate neurons in vivo revealing novel therapeutic potential for demyelinating disorders and traumatic nerve injury
Trainee in President’s Student Leadership Institute program
University of Maryland, Baltimore (UMB)
Baltimore, Maryland, United States
Accepted into and completed President’s Student Leadership Institute program, University of Maryland, Baltimore in 4 different tracks: Career Development, Entrepreneurship and Innovation, Effective Leadership and Wellness with attendance in required seminars/workshops
Graduate Research Assistant (Rotation project)
University of Maryland, Baltimore (UMB)
Baltimore, Maryland, United States
• Principal investigator: Dr. David Trisler/ Dr. Tapas K. Makar • Department of Neurology, University of Maryland, Baltimore • Project: Neuroprotective effects of brain-derived neurotropic factor (BDNF) analog 7, 8 dihydroxyflavone (DHF) treatment of experimental allergic encephalomyelitis (EAE) model. • Training: EAE induction and tissue isolation from mice, Immunohistochemistry and immunofluorescence analysis of optic nerve, retina and brain sections
Graduate Research Assistant (Rotation project)
University of Maryland, Baltimore (UMB)
Baltimore, Maryland, United States
• Principal investigator: Dr. Thomas J. Hornyak • Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore • Project: Study of BRCA1 cytoplasmic translocation through epigenetic regulation of E2 ubiquitin ligase UBE2E2 in melanoma • Training: Transfection, immunofluorescence, microscopy, immunoblotting
Graduate Research Assistant (Rotation project)
University of Maryland, Baltimore (UMB)
Baltimore, Maryland, United States
• Principal investigator: Dr. Eric J. Sundberg • Institute of Human Virology, University of Maryland, Baltimore • Project: Studying the interaction of tyrosine binding motifs (TPMs) of CagA, a virulence factor of Helicobacter pylori and adapter protein, Grb2 • Training: Isothermal titration calorimetry (ITC), mass spectroscopy, protein (endoglycosidase mutants) crystallization, protein isolation (Nickel column and Glutathione column) and purification (S200 size exclusion, GST or Mono Q column)
Research intern
University of Maryland, Baltimore (UMB)
Baltimore, Maryland, United States
• Principal investigator: Dr. Gerald Wilson • Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore • Project: Posttranscriptional regulation of gene expression by heat shock protein HSP70 by selective binding to mRNAs with AU-rich elements (AREs). • Training: Subcloning and protein expression with plasmids, Ni2+ affinity chromatography, fluorescence anisotropy, malachite green assay, immunoblotting
Research Intern
Baltimore City Community College
Baltimore, Maryland, United States
• Principal investigator: Dr. Kathleen Norris • Department of Biotechnology, Baltimore City Community College, Baltimore, MD • Project: Genetic comparison of different insect species • Training: DNA isolation from whole insects, DNA gels
Education
University of Maryland, Baltimore (UMB)
Biochemistry and Molecular Biology
Towson University
Molecular Biology, Biochemistry and Bioinformatics
Bishal Tandukar, PhD's Contact Information
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