Beatrice Brunkhorst PhD PMP

Senior Director Head of R&D Operations @ Actithera

About

The ultimate team player, I am an experienced Scientist who has driven over 15 drugs into the clinic. I enable startups to craft a fit for purpose framework to achieve their next milestone and drive their idea into the clinic. Experienced/passionate drug hunter specializing in services spanning from concept generation through Phase I/II for both biologics and small molecules. At this time, I am looking for full-part time/ hybrid/consultant roles based in Massachusetts with opportunities for travel. I look forward to connecting with you and can be reached at beabrunkhorst@gmail.com to discuss how I can immediately contribute to your team. Working both in Start-ups and Pharma have attained a broad knowledge of drug discovery from concept stage through early development, I have successfully led cross-functional global discovery and development project teams in Immuno-Oncology/Oncology to achieve the next milestone. I have managed global collaborations/studies externally with academic and commercial partners as well as performed due diligence and have a recognized track record for delivering key pharmacology data and strategies. As a dedicated Immuno-Oncologist/Cell Biologist, Director of Operations, Biosafety Officer with global experience in the Biotechnology/Pharmaceutical environment, I have successfully driven consistency and strength into both research and operations. Finally, my open and adaptive skills position me well to spearhead dynamic research, programming, and best in class solutions for your organizational culture, technology, and workflow. Technical Skills: Detailed Drug Discovery Journey Map with aggressive time lines, Research Data Quality, Pharmaceuticals, Biotechnology, Research and Development (R&D), Drug Development, Oncology, Cross-functional Team Leadership, Program Management, Strategic Development, Risk Management, Business Operations, Biosafety, non-regulated pre-clinical Quality, Regulatory Compliance People Skills: Adaptability, Critical Thinking, Problem Solving, Communication, Creativity, Teamwork, Attention to Detail, Time Management, Mentorship, Commitment to Community Service & Women in Leadership

Country

United States

City

Bedford

Industry

Biotechnology

Skill

Scenario Planning, Oncology, Issue Management, Global Experience, Communication, Activity Planning, Team Leadership, Public Speaking, Flow Cytometry, Emotional Intelligence, Research and Development (R&D), Microsoft Office, Business Development, Cancer Immunotherapy, Oncology Clinical Research, Data Analysis, Strategy, Validation (Drug Manufacture), Management, Leadership

Experience

Senior Director Head of R&D Operations

Actithera

2025-9 - Present · 1 yr 1 mo

Cambridge, Massachusetts, United States

Drive Radioligand Therapies to the Clinic Program Leadership/Management for emerging targets and assets going into the clinic.

Drug Discovery Consultant Delivering Timelines, Research Quality, Biosafety, & Project Management

Brunkhorst Consulting - Clients including Actithera Inc. & Fable Therapeutics

2023-7 - Present · 3 yrs 3 mos

Greater Boston

Experienced/passionate drug hunter specializing in services spanning from concept generation through Phase I/II for both biologics and small molecules. • Currently working with Actithera Inc., a radioligand company, to initiate Target/Phase I pre-clinical studies & program management frameworks. Enabled Series A readiness resulting in an oversubscribed fund raise. • Working with Fable Therapeutics translating AI generated results using Research Quality principles to enable Series A/B readiness, providing Drug Discovery Journey Map with aggressive timelines and full Research Quality program. • Areas of support include: program leadership/management, initiating pre-clinical and IND enabling studies, portfolio/resource assessment & strategic prioritization, research quality (Good Research Practice) & Biosafety. • My services are ideal for: Start-ups who are getting ready for investor/collaborator audits and those building start up infrastructure.

Director, Head of Translational Operations & Quality Management, RU Oncology & Biosafety Officer

EMD Serono, Inc.

2021-6 - 2023-3 · 1 yr 10 mos

Billerica, Massachusetts, United States

• Steered business excellence for the Research Unit (RU) Oncology Billerica group. • Drove Discovery Project support through founding the Discovery Project Lead Community, specific training programs and competitive intelligence. • Secured valuable relationships/output from collaborations with both academic and small Biotech’s. • Developed and fostered communities and communication in the Translational Biomarker Research group, Research Leaders, and Real-World Data Users. • Ensured Quality in the Global RU Oncology group as Head Quality Delegate for the global RU Oncology group through quality reviews/ELN checks/quality policy/quality training and representing RU Oncology in cross functional quality groups. • Chaired the Institutional Biosafety Committee (IBC), maintaining an excellent relationship with the Town of Billerica since 2004 and for EMD Serono since 1999.Coordinated the review for the permitting of rDNA/Lentiviral experiments campus wide. Performed day-to-day risk assessments for procurement of viral particles, cell lines, blood, and tissues. • Organized the safety/equipment/CAPEX/space planning for the RU Oncology Billerica Team. • Secured cross functional communication through organizing/leading meetings, providing documentation and follow-up. • Chaired/co-founded the Billerica Outreach Committee and co-Chaired the Women in Leadership Summit in 2022

Director, Head of Business and Scientific Operations TIP IO (Chief of Staff) & Biosafety Officer

EMD Serono, Inc.

2016-3 - 2021-6 · 5 yrs 4 mos

Billerica MA

• Ensured cross-functional alignment and communication of Translational Innovation Platform Immuno-Oncology (TIP IO) decisions on project and portfolio topics. • Initiated and enabled a new strategic portfolio prioritization within the TIP IO leadership team. • Provided direction to project team leaders, with respect to budget and resource allocation; also provided guidance to ensure adherence to benchmark performance criteria. • Oversaw TIP budget (CAPEX and OPEX) and progress of TIP portfolio, including internal/external collaborations. • Spearheaded global meetings including: Offsites, Leadership, Staff, Project Alignment (meeting with enabling research functions), Project Status, and Conference Debrief agenda/content. • Safeguarded organization of lab responsibilities including LN-2, biosafety hoods, etc. • Drove quality as Research Quality officer for Immuno Oncology Group 2012-2017, 2018- present. Represented TIP IO on Research Quality Council, Discovery Standards and Process Team, and Billerica Site Committee.

Global Project Lead - Oncology Development

EMD Serono, Inc.

2012-11 - 2016-2 · 3 yrs 4 mos

Billerica MA

• Drove strategic focus and operations for two multidisciplinary global research teams developing immuno-cytokines in Phase I/II. • Led team to secure endorsement for a Phase II combination with radiation and NHS IL2 in melanoma study. • Reinvigorated both NHS IL2 (2012-2018) and NHS IL12 (2013-2015) project teams and facilitated communication with external collaborators. • Finalized closure of the NHS IL2 Phase II melanoma study. • Initiated research plan on patient samples from the Ph II study and collected biomarker data that informed an ongoing IL2 program in TIP Immunology and resulted in a SITC poster in 2018. • Provided management with updates on internal and external IL2 molecules.