Baijun Kou

• Interpreted clinical samples for diagnostic purposes, providing detailed histological characterizations and biomarker quantification to determine clinical enrollment criteria, drug efficacy phenotype and prediction of ORR/recurrence rate for study protocol development • Led validation of immunohistochemistry (IHC) assays for biomarkers development to support various companywide programs, including IO-Bispecific, ADC, Car-T, autoimmune and metabolism drug development and for target CDx development • Collaborated with research, translational and clinical teams to align priorities, delivering expertise in biomarker validation, indications prevalence analysis, and digital multiplex data analysis (IHC, multi-IHC, IF, ISH) in both animal model and patient specimen • Conducted extensive literature search, performed competitive landscape analysis, engaged with KOLs for the identification of novel targets and clinical development strategy plan • Established a novel clinical biomarker validation and development platforms to serve cross-functional teams from pre-clinical IPA, First-in-Human studies through Phase II clinical trials • Developed clinical pharmacology assessment strategy for Phase II/III study and performed data analysis to support pre-market application • Characterized and annotated H&E samples for genomic analysis, scRNAseq, proteomics analysis and integrated data to determine biomarker development plan • Collaborated with clinical team for patient monitor analysis and provided interpretation for drug safety evaluation and AE prevention • Participated and presented data at scientific advisory boards to support program, be responsible for selection and delivery of pharmacodynamic and biomarker assays • Provided scientific rationale and pathological evaluation in the innovative design, execution, and data interpretation of clinical studies to support IND, NDA filling and labelling for FDA approval

• Reviewed research proposals, offering pathological expertise for biomarker focused projects to ensure scientific rigor and alignment with study goals • Employed RNA scope (ISH) and laser capture microdissection (LCM) techniques for RNA expression, single-cell RNA sequencing and Mass-Spec analysis • Leveraged multiple web-based tools to analyze TCGA datasets and inform biomarker target selection • Collaborated with computer scientists to drive advancements in digital pathology research and data analysis • Evaluated immuno-checkpoint biomarkers and conducted IHC imaging data analysis, supporting patient selection strategies for immune-oncology clinical trials • Provided pathology expertise in selecting research cases for immunotherapy and targeted therapy studies

• Utilized molecular and cellular biology techniques for biomarker development across multiple projects involving human and animal subjects, contributing to cross-institutional research efforts • Developed and optimized new antibody-based assays for disease characterization • Developed multiplex IHC methodologies and applied machine learning algorithms to improve imaging data analysis accuracy • Served as a research pathologist, analyzed H&E slides from patient samples to support the cancer center’s tissue bank and advance research initiatives • Designed research proposals for tissue-based clinical studies and built productive collaborations with clinicians • Collaborated with CRAs to monitor patient outcomes and evaluate targeted therapy effects and safety vigilance • Created a research database for data management and used a range of software packages for comprehensive data analysis • Engaged with industry partners for pathology-related collaborations, expanding external partnerships • Prepared presentations, authored research papers, and contributed to funding applications • Supervised junior staff and managed the research budget, ensuring effective resource allocation and team development.

• Led histopathology and molecular pathology initiatives to support all R&D projects to support PET/ SPECT/CT/MRI/Ultrasound scan agent development for disease detection and therapeutic monitoring • Conducted biomarker identification, antibody selection and validation, and imaging data analysis for both pre-clinical and clinical studies • Led multiple research projects within a matrix team, from Proof of Mechanism (PoM) stages through clinical Phase II trials • Developed SOP for histology and pharmacology study and selected CROs to conduct these studies • Analyzed pathology and pharmacology study data, prepared technical reports, and presented findings to stakeholders for informed decision-making • Conducted scientific background analyses to assess project feasibility for IRB review and facilitate FDA and EMEA applications • Designed new projects and reviewed existing projects to support clinical operations and research process • Collaborated with global project management teams to meet project milestones on time and within budget, partnered with preclinical and clinical teams to accomplish study objectives • Assessed pre-clinical data and prepared essential documents for IND applications • Developed patient enrollment criteria and drafted clinical trial protocols, including ICFs and IB; conducted data review and analysis, Drafted clinical study report • Built partnerships with academic institutions for external collaborations and facilitated technology transfer

• Conducted research to investigate and identify biomarkers for early cancer detection and cancer progression • Characterized biomarkers and their pathways via molecular and cellular biology techniques, alongside animal models, to deepen understanding of cancer mechanisms • Designed biomarker clinical research projects and prepared pathology study protocols • Collaborated with clinicians to implement studies and classify specimens in adherence to ICH-GCP guidelines and clinical diagnostic standards • Validated selected biomarkers and performed IHC staining on clinical specimens, supporting reliable biomarker assessment and study accuracy • Managed high-throughput digital scanning and data archiving of slides using the Aperio system, streamlining data collection and accessibility • Established pathological analysis criteria and conducted comprehensive reading and scoring of slides to ensure consistent and accurate evaluation • Supervised Master’s and Ph.D. students in conducting research projects, fostering academic growth and contributing to research outcome • Prepared and delivered presentations, reports, and research papers, sharing findings at national and international conferences