Aurélien FLATRES, PhD

Translational research manager @ Abivax

About

Attracted by the understanding of various physiological dysfunctions, I followed a research training with a Bachelor and a Master degree in the field of physiopathology. Then, during my PhD, I had the chance to work on an ambitious project combining clinical studies and tissue engineering techniques about skeletal muscle weakness. I currently work at Abivax, a french company which is developing Obefazimod (international phase 3 program), a promising drug to fight autoimmune inflammatory diseases. With my colleagues I'm in charge of translational research activities coordinating the different CROs involved.

Country

United States

City

Cambridge

Industry

Biotechnology

Skill

Good Clinical Practice (GCP), Recherche médicale, Gestion des échantillons, Gestion de la chaîne logistique, Système qualité, Essais cliniques, Gestion de projet, Microsoft Office, Leadership, Planification stratégique, Formation, Public Relations, Biologie moléculaire, Biologie cellulaire, Anglais, Recherche, Biomatériaux, Gestionnaire de données biomédicales, Parler en public, Cellules souches

Experience

Translational research manager

Abivax

2024-4 - Present · 2 yrs 6 mos

Boston, Massachusetts, United States

Translational research manager

Abivax

2021-12 - Present · 4 yrs 10 mos

Montpellier, Occitanie, France

My work is focus on the management of all the CROs involved in translational research for different Abivax clinical studies (from phase 1 to phase 3). Theses CRO are : - In charge of central laboratory (phase 3 program, over 1200 patients scheduled) - In charge of biobanking (more than 45 000 samples stored) - In charge of all biological analysis : cytokines level measurement, histopathology scoring, DNA-RNA quantification (over 35 000 samples expected for phase 3 only) - In charge of statistical analysis (for 3 clinical trials) I'am also dedicated to two others key responsabilites : - Monitor the appropriateness of the rules relating to the biological samples (CGP, GCLP, clinical study protocol...) - Propose new biological analyses to develop an innovative drug to the market (Obefazimod program)

Young research (PhD program)

Physiology and experimental medicine (PhyMedExp) - CHU / Laboratoire charles coulomb (L2C)

2017-11 - 2021-5 · 3 yrs 7 mos

Université de Montpellier, France

As young researcher following a PhD training program in regenerative medicine, my objective was to bring new knowledge about muscle regeneration dysfunction observed in intensive care patient. My thesis project had a double goal. The first was to assess the potential of a new diagnostic ultrasound method on a cohort of 100 patients. The second was to develop a diagnostic tool for modeling skeletal muscle (organoids field) using tissue engineering techniques. I published two articles and succeeded in developing a first prototype of muscle organoids.

Intern

MitoVasc Institute

2016-10 - 2017-7 · 10 mos

Région de Angers, Pays de la loire, France

I took part in a research project relating to the molecular mechanisms involved in the renal protection induced by the estrogen receptor during cell aging. I acquired : - Project management skills - Scientific communication skills - Basic science knowledge - Various biological methods : qPCR, IHC, histopathology

Intern

Laboratoire ORPHY (Optimisation des régulations physiologiques)

2015-7 - 2015-8 · 2 mos

Région de Brest, France

I took part in a research program on the effect of physical training on type II diabetes. Basic science learning : Cell culture, western blot.

Education

University of Montpellier

Physiology and regenerative medicine

2017-10 - 2021-5 · 3 yrs 8 mos

University of Montpellier

Biotechnology

2019 - 2019

Lifelong learning centre with an introduction to the field of implantable medical devices: - Chemical synthesis / characterization of (bio)materials - Hydrogels and silicone for tissue engineering - Device degradation and sterilization - Cellular biocompatibility - Surface engineering - Regulatory concepts