Aurelio del Pino Beitia

• Management of the clinical trials unit. • Define and monitor the unit strategy and objectives. • Line management of the team. • Propose, establish, and maintain relationships with an extended network of existing and potential clients for clinical development strategy acting as primary point of contact for all business-related inquiries. • Identify and study new companies that could need clinical development strategy, examining risks and potential of future collaborations, and estimating partners' needs and goals. • Propose, establish, and maintain relationships with other stakeholders in independent clinical research, such as Private Foundations or Public Funds. • Explore collaborative models between clinical partners to accelerate clinical development of innovative treatments. • Present and pitch company services and added value to potential clients, showcasing our expertise, capabilities, and unique value proposition. • Work closely with existing and potential clients to understand their research requirements and needs to coordinate with internal stakeholders and develop a tailored strategic service and/or clinical development strategy. • Collaborate with cross-functional teams to ensure timely and effective opportunities development and communication with existing and potential funders. • Provide support in the design, development, and present scientific, operational, and market-based documentation, including abstracts, posters, protocols, presentations, market analysis reports or articles. • Collaborate in specific forums, media, and publications to position the company's branding highlighting the added value and differential. • Develop and maintain a deep understanding of industry trends, market dynamics, and competitive landscape to ensure our offerings remain relevant and competitive. • Utilize Customer Relationship Management (CRM) tool to track leads, opportunities and interactions to provide regular reports. • Support and guide other departments.

• Propose, establish, and maintain relationships with an extended network of existing and potential funders for clinical development strategy acting as primary point of contact for all business-related inquiries. • Identify and study new companies that could need clinical development strategy, examining risks and potential of future collaborations, and estimating partners' needs and goals. • Propose, establish, and maintain relationships with other stakeholders in independent clinical research, such as Private Foundations or Public Funds. • Present and pitch company services and added value to potential clients, showcasing our expertise, capabilities, and unique value proposition. • Work closely with existing and potential funders to understand their research requirements and needs to coordinate with internal stakeholders and develop a tailored strategic service and/or clinical development strategy. • Collaborate with cross-functional teams to ensure timely and effective opportunities development and communication with existing and potential funders. • Provide support in the design, development, and present scientific, operational, and market-based documentation, including abstracts, posters, protocols, presentations, market analysis reports, articles, etc. • Collaborate in specific forums, media, and publications to position the company's branding highlighting the added value and differential. • Develop and maintain a deep understanding of industry trends, market dynamics, and competitive landscape to ensure our offerings remain relevant and competitive. • Utilize Customer Relationship Management (CRM) tool to track leads, opportunities and interactions to provide regular reports and updates to Business Development team. • Collaborate with other departments providing support and guidance when needed.

Supporting early-stage biotechs in structuring their clinical strategy from preclinical stages, including fundraising readiness and clinical outsourcing preparation with CROs. Focused on governance, operating models and sustainable decision-making before entering clinical development.

Experience in first-in-human to phase III Hematology, CART and Immunology studies. Tasks: - Supervise in-house staff, ensuring compliance of staff with SOPs and international/local regulation - Representative of the country in the study team. Collaborate with Global Project Manager to set and comply with project goals. -Recording and sharing interactions with other stakeholders, acting as representative. - Create and implement study-specific clinical monitoring tools and documents. - Management and approval of local documents - Conduct country/site feasibility and investigator selection - Define the expected country study budget, ensuring costs and resources optimization - Coordinate local Health Authorities and IRB/EC activities - First-level support in issue resolution - Oversight of patient recruitment - Preparation, review and conduct of training. Conduct regular team meetings - Visit report review and implementation of the Monitoring Plan at country level - Responsible of data quality and database locks - Ensure study drug and study materials traceability - Ensure proper notification, documentation and escalation of protocol or GCP non-compliance - Ensure compliance and completion of essential documents and eTMF, as required - Assist Global Project Managers in finding resolution (audits, inspections or quality visits) Core competences and skills: - Extensive knowledge of therapeutic area, monitoring activities, internal procedures and policies, regulation and GCPs - Excellent written and oral communication skills - Ability to act as team player to work in a cross-functional team environment - Organizational, prioritization and time management skills - ability to effectively multi-task - Ethic behaviour - Global view by ensuring the study goals and timelines - Focused on quality - Critical view to identify trends and implement action plans - Effective problem solving and decision-making skills - Ability to build excellent working relationships

Oversight of outsourced immunology and inflammation (I&I) clinical trials: Tasks: - Key point of contact in the affiliate between CRO, site and international team - Provide support in country/site feasibility, site/investigator selection and start-up activities - Support in achieving the recruitment goals - Regular meetings with our partners CROs to check the projects on an ongoing basis - Identify trends and issues that may arise - Collaboration with MSL team - Attend study visits (specially pre-study, initiation and motivational visits)

Clinical Trial Manager Early Development Hematology and Immunology studies and Senior Clinical Research Associate for Cell Therapy studies Tasks as Clinical Trial Manager: - Supervise local team, ensuring compliance of staff with SOPs and international/local regulation - Representative of the country in the study team. - Collaborate with Global Team to set targets, ensuring compliance with project goals. - Create and implement study-specific clinical monitoring tools and documents. - Management and approval of local documents and local vendors - Conduct country/site feasibility and investigator selection - Define the expected country study budget, ensuring costs and resources optimization - Coordinate local Health Authorities and IRB/EC activities - First-level support in issue resolution - Oversight of patient recruitment - Preparation, review and conduct of training. Conduct regular team meetings - Visit report review and implementation of the Monitoring Plan at country level - Responsible of data quality and database locks - Ensure proper notification, documentation and escalation of protocol or GCP non-compliance - Ensure compliance and completion of essential documents and eTMF, as required - Assist Global Project Managers in finding resolution (audits, inspections or quality visits) Core competences and skills: - Extensive knowledge of therapeutic area, monitoring activities, internal procedures and policies, applicable regulation and GCPs - Excellent written and oral communication skills - Ability to act as team player to work in a cross-functional team environment - Organizational, prioritization and time management skills - ability to effectively multi-task and prioritize - Ethic behaviour - Global view by ensuring the study goals and timelines - Focused on quality - Critical view to identify trends and implement action plans - Effective problem solving and decision-making skills - Ability to build excellent working relationships

Lead Clinical Research Associate for EU in a phase I Hematology clinical trial. Participation in taskforces and initiatives to review procedures, prepare materials and perform department trainings. Tasks: - Representative of the monitoring activities in the study team - Team coordination and first-level support in issue resolution - Preparation and update of annotated visit reports - Monitoring visit report review - Support CRAs by conducting accompanied or co-monitoring visits - Development and ongoing review of the Monitoring Plan - Set up and moderation of monitoring calls - Facilitate study accessess - Adaptation, preparation and distribution of study related documentation - Preparation and review of training materials, ensuring compliance in the monitoring team training - Support team in Regulatory and IRB/EC activities - Assist Project Managers in finding resolution (audits, inspections or quality visits) - Collaborate in the Quality Management Plan development by identifying issues that may affect monitoring activities Core competences and skills: - Extensive knowledge of therapeutic area, monitoring activities, internal procedures and policies, applicable regulation and Good Clinical Practices - Excellent written and oral communication skills including presentations - Ability to act as team player to work in a cross-functional team environment - Organizational, prioritization and time management skills - ability to effectively multi-task and prioritize - Ethic behaviour - Global view by ensuring the study goals and timelines - Focused on quality - Critical view to identify trends and implement action plans - Effective problem solving and decision-making skills - Ability to build excellent working relationships – internally and externally

Clinical Research Associate for early phase clinical trials in Hematology and Oncology Job description: • Overall site management. • Knowledge of applicable international and national regulations. • Site visits: Motivational, Qualification, Initiation, Monitoring and Close-Out Visits. • Review of the Informed Consent (IC) process. • Ensure that all Adverse Events (AEs)/Serious Adverse Events (SAEs) are reported appropriately, accurately and followed-up in a timely manner. • Acquire clinical knowledge about the therapeutic area. • Source Data Verification (SDV) and management of electronic Case Report Forms (eCRFs). • Follow-up open issues/queries until resolution. • Ensure compliance with protocol and notify Protocol Deviations (PDs). • Organization, accountability and reconciliation of Investigational Product (IP) and trial supplies. • Experience with Clinical Trial Management System (CTMS) and several Vendors. • Maintenance of Trial Master File (TMF) and Investigator/Pharmacy Site Files (ISF/PSF). • Preparation, handling, distribution, filing, and archiving of clinical documentation and reports according to the scope of work and standard operating procedures • Continuous apprentice in therapeutical areas (scientific sessions, congresses, etc.).

Clinical Research Associate for early phase clinical trials in Hematology and Oncology Job description: • Overall site management. • Knowledge of applicable international and national regulations. • Site visits: Motivational, Qualification, Initiation, Monitoring and Close-Out Visits. • Review of the Informed Consent (IC) process, IC Form adaptation to local guidelines. • Ensure that all Adverse Events (AEs)/Serious Adverse Events (SAEs) are reported appropriately, accurately and followed-up in a timely manner. • Acquire clinical knowledge about the therapeutic area. • Source Data Verification (SDV) and management of electronic Case Report Forms (eCRFs). • Follow-up open issues/queries until resolution. • Ensure compliance with protocol and notify Protocol Deviations (PDs). • Organization, accountability and reconciliation of Investigational Product (IP) and trial supplies. • Experience with Clinical Trial Management System (CTMS) and several Vendors. • Maintenance of Trial Master File (TMF) and Investigator/Pharmacy Site Files (ISF/PSF). • Preparation, handling, distribution, filing, and archiving of clinical documentation and reports according to the scope of work and standard operating procedures • Continuous apprentice in therapeutic areas (scientific sessions, congresses, etc.).

Clinical Research Associate for multicenter, international studies, from first-in-human to phase III, in different therapeutic areas: Cardiology (Acute Myocardial Infarction), Rheumatology (Osteoarthritis), Dermatology (Epidermiolysis Bullosa), and Infectious Diseases (Clostridium-Difficile Associated Diarrhea). Job description: • Overall site management. • Knowledge of applicable international and national regulations. • Site visits: Motivational, Qualification, Initiation, Monitoring and Close-Out Visits. • Review of the Informed Consent (IC) process. • Ensure that all Adverse Events (AEs)/Serious Adverse Events (SAEs) are reported appropriately, accurately and followed-up in a timely manner. • Acquire clinical knowledge about the therapeutic area. • Source Data Verification (SDV) and management of electronic Case Report Forms (eCRFs). • Follow-up open issues/queries until resolution. • Ensure compliance with protocol and notify Protocol Deviations (PDs). • Organization, accountability and reconciliation of Investigational Product (IP) and trial supplies. • Experience with Clinical Trial Management System (CTMS) and several Vendors. • Maintenance of Trial Master File (TMF) and Investigator/Pharmacy Site Files (ISF/PSF). • Preparation, handling, distribution, filing, and archiving of clinical documentation and reports according to the scope of work and standard operating procedures • Continuous apprentice in therapeutical areas (scientific sessions, congresses, etc.).

• 2015 Research Project in Neurosciences and Pharmacology called “In vitro characterization PDZ-binding motif of Kidins220 and their roles in neuroprotection" performed as a part of the Master Thesis and under direction of Dr. Teresa Iglesias in Instituto de Investigaciones Biomédicas Alberto-Sols Madrid (Spain). •2012-2014 Research Project in Epigenetics and Cancer called“Assesing the role of DNMT1 protein in maintenance of the nuclear architecture and cell competition”. First performed as a part of the Diploma Thesis and thereafter as collaborator. This project was leaded by Dr. Jesús Espada with collaboration of Dr. Juan José Arredondo Lamas in Instituto de Investigaciones Biomédicas Alberto-Sols Madrid (Spain). •2012 Apprenticeship in a Genomics & Bioinformatics Project called “CRISPR immune system characterization in Synechocystis PCC6803 to optimize biofuel production” under direction of Prof. Dr. Wolfgang Hess in the University of Freiburg (Germany). •2012 Apprenticeship in a Developmental Biology Project called “Searching the interaction sequence of Ubx (Ultrabithorax) protein to activate Thickveins D gene expression and their implications in fly appendages development in Drosophila melanogaster” under direction of Dr. Gyorgos Pyrowolakis in the university of Freiburg (Germany). Key areas of Responsibility: • Experimental Techniques in Molecular Biology and Biochemistry. • Cell and bacteria culture. • Handling and Maintenance of Animal Model Organisms. • Immunodetection, immunoblot and Staining Techniques. • Flow Cytometry. • Techniques in Microscopy. • Scientifical writing. • Participation in Seminars and Conferences.. Acquired competences: LABORATOY SKILLS, COMMUNICATION, ORGANIZATION, TEAMWORK. SCIENTIFIC SKILLS

Teaching and support in science-related subjects to students either from Secondary School or High School. I also supported students to pass University Entrance Examination.

Management, production, assistance and coordination of audiovisual events as an eventual job.

Assembly, management, production, assistance and coordination of audiovisual events as an eventual job.