Anissa Belfetmi-Stone Ph.D.

Patent prosecution ✦ Patent drafting ✦ IP ✦ Due diligence ✦ Global landscape ✦ Due diligence ✦ Tech transfer • Review technical disclosures and participate in client interviews to understand new inventions • Searching literature and patent databases to determine the patentability of inventions • Drafting IP due diligence of the prospects of obtaining patent protection • Writing patent applications • Preparing responses to communications from the U.S. Patent and Trademark Office • Developing arguments for patentability to Patent Office Examiners (U.S., CA, EP, JPD, CN, HK, AU) • Conduct IP due diligence assessments and evaluate patent portfolios to inform acquisition decisions and identify risks/opportunities • Working with the Business Development team to improve client experience

Stephen C. Harrison lab, HHMI, Biological Chemistry & Molecular Pharmacology Department & BCH

Gerhard Wagner lab, Biological Chemistry & Molecular Pharmacology

Mark Namchuk lab, Q-FASTR & Biological Chemistry & Molecular Pharmacology Department

James J. Chou lab, Biological Chemistry & Molecular Pharmacology Department Research project: "Study of Tumor Necrosis Factor Receptor Superfamily (TNFRS) preligand association (PLAD)." Membrane Protein ✦ Lipid ✦ Immune receptors ✦ Protein labelling ✦ FRET ✦ SEC-MALS ✦ DLS ✦ HPLC ✦ FPLC ✦ TEM ✦ NMR

Melissa Leger-Abraham Lab, Microbiology Department RNA binding proteins ✦ mRNA translation ✦ mRNA capping & decapping ✦ RNA & protein purification ✦ Pull-down assay ✦ RNases ✦ In Vitro transcription ✦ RNA methylations

Though Tech ✦ Risk Mitigation ✦ IP ✦ Business Model ✦ Regulatory ✦ Scale Up ✦ Commercialization • Participated in a non-resident program to explore the commercial opportunities for a Tough Tech breakthrough from my research in the lab and build a roadmap for a startup creation • Identified potential applications from academic benchtop science to address real-world challenges • Evaluated consumer needs to develop and implement a viable business model • Prepared a budget estimate to run a biotech company and the fundraising needs • Addressed the scaling-up process for commercial viability • Navigated the complexity of the regulatory environment

Analysis of early commercialization cases to translate scientific innovation from Harvard to a meaningful industry application. Harvard Office of Technology Development (OTD) Problem analysis ✦ IP ✦ Market analysis ✦ Competitors’ landscape ✦ Licensing ✦ Collaborations • Consults for Harvard clients on market research, potential licensees, and patent prior art searches • Identifies potential market applications in life science patents • Suggest collaborators and partnerships to transfer the technology from academia to industry (Pharma, CRO, CDMO).

RNA labeling/purification ✦ RNA secondary structure ✦ RNA/DNA annealing ✦ Oligonucleotides ✦ CD ✦ NMR ✦ Anisotropy of fluorescence ✦ EMSA shift assay

I joined the team of structures and interactions of nucleic acids within the Laboratory of Biology and applied Pharmacology (LBPA CNRS UMR 8113) in order to study the structural and interaction properties of the mature HIV-1 Nucleocapsid Protein (NCp7) with its nucleic acid partners (DNA and RNA). Using Biophysics (Fluorescence Anisotropy, FRET, Circular Dichroism, NMR spectroscopy) and Biochemistry methods (EMSA shift assay).