Alexander Mitkas

Principal Scientist - Translational Sciences/DMPK @ Paragon Laboratories, Inc.

About

Chemical and Biomolecular PhD candidate working on controlling intracellular metabolic flux through dynamic protein assembly and disassembly. Experienced in molecular cloning techniques,protein engineering, RNA, protein, and metabolite analysis, bacterial and mammalian cultures, and data analysis. Interested in all things synbio.

Country

City

United States

Industry

Pharmaceuticals

Skill

Protein Engineering, Synthetic Biology, Molecular Cloning, High-Performance Liquid Chromatography (HPLC), Western Blotting, Protein Purification, Protein Expression, Flow Cytometry, Animal Models, MATLAB, Microsoft Excel, Microsoft PowerPoint, Bacterial Cell Culture, Mammalian Cell Culture, Aspen Plus, COMSOL, RNA Isolation, Immunoprecipitation, PCR Primer Design, Mouse Handling

Experience

Principal Scientist - Translational Sciences/DMPK

Paragon Laboratories, Inc.

2025-6 - Present · 1 yr 4 mos

Principal Scientist - Translational Modeling and Simulation

Pfizer

2024-6 - 2025-5 · 1 yr

Cambridge, Massachusetts, United States

Supporting a wide array of projects in the Pharmacokinetics, Dynamics, and Metabolism group (PDM) . Current project areas include inflammation & immunology and internal medicine. Developing complex PKPD models in collaboration with analytical teams to make informed decisions about drug properties (affinity, avidity, etc.) and predict dosage levels in humans.

Senior Scientist - Translational Modeling and Simulation

Pfizer

2022-2 - 2024-6 · 2 yrs 5 mos

Cambridge, Massachusetts, United States

Supporting a wide array of projects in the Biomedicine Design Group (BMD). Project areas include oncology, inflammation & immunology, rare diseases, and internal medicine. Developing complex PKPD models in collaboration with analytical teams to make informed decisions about drug properties (affinity, avidity, etc.) and predict dosage levels in humans.

PHD Candidate

University of Delaware

2015-9 - 2022-1 · 6 yrs 5 mos

Developed a dynamic, high affinity, modular scaffold toolkit for control of intracellular metabolic flux in bacteria. Used Cas6 proteins and RNA to achieve high affinity and dynamic dis-/assembly respectively. Demonstrated increased production of both native and nonnative metabolites in E.coli. Developed excellent molecular cloning, cell culture, and analytical (protein/RNA/metabolite) skills.