Alexa Warner

• Supported the Chief Operating Officer in coordinating and managing cross-functional teams across medical affairs, regulatory, preclinical, and clinical domains. • Led communication and coordination efforts with clinical sites, monitors, and external vendors to streamline operations. • Directed company branding initiatives, including website redesign, enhancing the social media presence, and optimizing outward-facing materials to strengthen the organization’s image. • Oversaw the preparation and organization for industry conferences, including developing presentation materials and coordinating investor engagement strategies. • Conducted competitive intelligence research for internal programs and attended industry conferences to gather insights and inform strategic planning. • Facilitated communication and identified potential collaborators to integrate innovative technologies, such as partnerships with companies specializing in artificial intelligence and machine learning. Identified external methodologies for data collection to enable comparator analysis and inform strategic decision-making. • Delegated and assigned tasks to develop direct reports, fostering professional growth and ensuring alignment with organizational objectives. • Contributed to financing and fundraising efforts by creating strategic data presentations and delivering compelling narratives to engage stakeholders. • Designed and implemented creative scientific presentations using figures, illustrations, and visual designs tailored to engage and resonate with diverse audiences. • Analyzed data innovatively to uncover actionable insights and proposed additional assessments that enhanced clinical study design and maximized study outcomes. • Developed creative statistical methodologies to deepen understanding of complex datasets and support evidence-based decision-making.

• Lead weekly company meetings, delivering action items, potential obstacles, and project analysis based on study progress and timeline management. • Collaborated with multidisciplinary teams to streamline the development and execution of clinical trials. • Organized and maintained trackers for study progress, reviewed site visit reports, and data monitoring summaries. • Prepared clinical trial documents, such as case report forms and study close-out materials, ensuring adherence to regulatory requirements. • Created slide decks summarizing clinical findings for presentation to internal members, principal investigators, and potential and current stakeholders. • Conducted statistical analyses on preclinical and clinical trial data, including both preliminary and final findings, to derive actionable insights. • Performed ad hoc analyses to identify additional opportunities for leveraging data. • Developed visual aids for statistical readouts, such as graphs and tables, utilizing software platforms including Python and GraphPad Prism. • Contributed to clinical study reports by applying advanced writing skills and medical terminology to ensure accuracy and clarity. • Created tables, listings, and figures integrated into regulatory reports submitted to the FDA, supporting compliance and facilitating effective communication of findings.

• Conducted ongoing literature analysis consistent with the company's scope of interest to utilize the latest research and methodologies. • Aided in preclinical study design through valuable input on research methods and future statistical analysis plans. • Played a vital role in the organization of data management, data validation, and data analytics for preclinical and clinical trials. • Attended and actively engaged in academic and industry research conferences. Fostered professional networks and remained up-to-date with the latest advancements in the field. • Presented research findings to colleagues and tailored discussions for various audiences, including external members, impacted families, and key opinion leaders. • Collaborated with clinical research organizations to optimize study and trial design, working effectively with multidisciplinary teams and bridging academia and industry fields. • Contributed to the preparation of regulatory documents, including protocols, investigator brochures, and clinical study reports. • Assisted in organizing and participating in study initiation, document collection methods, and site activation tasks.

• Prepared high-quality samples for next-generation sequencing and utilized previous advanced molecular biology techniques, including cloning through plasmid preparation and maintaining electronic lab notebooks, to generate and validate antibody libraries, supporting antibody discovery, optimization, and humanization efforts. • Operated specialized instruments to facilitate antibody analysis and discovery, while employing ELISA techniques for antibody binding assessment in screening and characterization. • Performed advanced mammalian cell culture techniques (HEK293 and T-cell lines), ensuring high cell viability and reproducibility for cell-based assays designed to screen and characterize therapeutic antibody candidates. • Optimized functional and binding assays in collaboration with cross-functional teams, advancing the antibody discovery pipeline and identifying high-potential therapeutic leads. • Coordinated safety efforts and ensured strict adherence to laboratory safety standards as lead in the Environmental Health & Safety group. • Managed the Safety Data Sheet database and obtained Department of Transportation certification to aid in compliance with hazardous material handling and transportation protocols.

• Conducted DNA extraction, quantification, and sequencing data analysis to verify the accuracy and integrity of results. • Validated DNA constructs for single-domain antibody development using advanced cloning techniques. • Performed plasmid preparation, restriction enzyme digestion, ligation, and PCR amplification for gene expression studies. • Isolated high-quality DNA and RNA from cell cultures, assessing purity via spectrophotometry and fluorometry. • Supported bacterial and mammalian cell culture systems for construct propagation, including transfections, antibody expression monitoring, and protein expression validation. • Operated and maintained molecular biology instruments, including PCR machines, gel electrophoresis units, and sequencing platforms. • Accurately documented experimental procedures in electronic lab notebooks and generated comprehensive reports for cross-functional team collaboration. • Contributed to the development and improvement of experimental protocols and workflows, increasing efficiency in plasmid purification and DNA quantification processes.

• Conducted colony picking and bacterial growth in media for plasmid isolation. • Performed bacterial harvesting, plasmid DNA extraction, and plasmid quantification using spectrophotometry and fluorometry. • Ran PCR amplification and gel electrophoresis to verify PCR products and confirm plasmid integrity. • Assisted with plasmid purification and sent samples out for sequencing. • Prepared agar plates, stock solutions, and maintained accurate batch records to ensure consistency and quality control. • Contributed to the creation of data repositories and improved data storage practices, ensuring adherence to quality measures. • Provided training to new interns and streamlined training procedures to improve onboarding processes. • Assisted with ordering lab supplies, maintaining stock levels, and sterilizing lab environments, demonstrating commitment to safe lab practices. • Collaborated with lab members, offering support in urgent procedures through pipetting and other lab tasks.

• Collaborated with the PI in the analysis of fMRI data, reviewing collected scans and discussing potential relationships between brain regions' signaling, with a focus on learning and developing a deeper understanding of neuroimaging techniques. • Contributed to the development of novel quantitative fMRI techniques, aiding in the creation of a comprehensive database for interpretation. • Administered cognitive functioning exams, screened and recruited eligible participants, and ensured adherence to eligibility criteria in alignment with study objectives. • Led recruitment initiatives and assisted with raising awareness of the study through outreach efforts, in collaboration with the study lead. • Managed participant scheduling, tracked trial information via Ripple Science and RedCap, and ensured adherence to approved protocols and IRB guidelines. • Operated in fMRI machine rooms, assisting with participant preparation, administering tests during scanning procedures, and ensuring participant comfort and safety throughout the process.

• Collaborated closely with the Chief Financial Officer (CFO) to support the efficient management of financial operations, gaining exposure to key business initiatives and operational requirements. • Managed the accurate and timely data entry and organization of legal documents, invoices, purchase orders, and receipts, contributing to the smooth execution of daily financial functions. • Supported the preparation of budgets and expense analyses, helping to develop a foundational understanding of financial planning, forecasting, and cost management. • Assisted with organizing and entering data for audits, working with the CFO and external auditors to ensure compliance with regulatory standards and financial reporting requirements. • Gained hands-on experience with financial data management, improving attention to detail and establishing a strong foundation for managing complex datasets in a business context.