Aiping Bai

Program and team management, novel target identification, new program proposal Generation, characterization, and discovery of antibodies against immune checkpoint proteins and tumor markers. Regulation of onco- and auto-immunity including immune cell (CD4, CD8, macrophage, NK, DC cells etc) signals and functions in vitro and in vivo by antibodies against immune checkpoints. Establishment of immunological methodology inclusive of ADCC, phagocytosis, antibody-related signals and immune cell biology (proliferation, apoptosis, etc), as well as in vivo models. Antibody and bispecific antibody generation, characterizations (EC50, KD, epitope, purity, cross-reactivity), in vitro and in vivo bio-functions determination for therapeutical purposes. Projects manager/leader leading an immunological research team. Manager of flow cytometry core.

Bio-functions and signals of human endothelial cells triggered by patient blood antibodies. Interactions between endothelial cells and immune cells. Stem cell identification from human PBMCs. Animal models studying carcinogenesis and sepsis. Biomarker development.

Translational Immunology, mucosal immunity, including human CD4, CD8 T cells, macrophages, DC, NK cells, in association with human immune diseases: Immune cells and subsets isolation from human and murine blood, PBMCs, and tissues (colon, liver, spleen, lung, tumor, etc). Ex vivo and in vitro immune cell function (signals, activation, proliferation, cytokines, etc) by flow cytometry, ELISA, western blot, confocol, and realtime imaging system. T cell, macrophage, and DC differentiation, and the related cell signals. Immune disease models, including GVHD, colitis, sepsis, asthma, spontaneous or/and chemical/cells induced cancer models. Immune cell function-associated markers, pharmacology, drug discovery. Clinical and translational studies and clinical trials using healthy and patient tissues, blood, and clinical data.

Regulation of immune responses by cell signals: CD4 T cell and macrophage differentiation and functions in vivo and in vitro. Cell signaling pathways inclusive of mTOR, AMPK, NFkB, etc, and regulation by small molecules. T cell and macrophage responses in murine models of colitis, arthritis, sepsis, asthma, and inflammation-associated cancers. Immune cell isolation techniques: isolate T cells and monocytes/macrophages from blood, spleen, peritoneum, bone marrow and organ tissues.